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| Sun, X.; Rogoff, H.; Li, C. |
Asymmetric RNA Duplexes Mediate RNA Interference in Mammalian cells
Nature Biotechnology Vol. 26 (12). Dec. 2008
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| Abstracts presented on AACR annual meeting 2007 |
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ARQ 197, a highly selective small molecule inhibitor of c-Met, inhibits invasive and metastatic growth of cancer cells.
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Broad spectrum anti-cancer activity of ARQ 197, a highly selective oral c-Met inhibitor, in multiple xenograft models.
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Anti-metastatic activity of ARQ 197, a highly selective oral small molecule inhibitor of c-Met, in experimental metastatic models of colon cancer.
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Functional chemogenomics approach to identify checkpoint pathway activators against cancer.
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Selective induction of necrotic cell death in cancer cells by (beta)-lapachone through activation of DNA damage response pathway.
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Selective killing of cancer cells by activation of human checkpoint kinase 2.
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Mikule, K.; Delaval, B.; Kaldis, P.; Jurcyzk, A.; Hergert, P.; Doxsey, S.
Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest
Nat Cell Biol Vol. 9 (2) 160-70. Feb. 2007
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Li, C. J.
Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference
J Cell Physiol Vol. 209 (3) 695-700. Dec. 2006
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Sun, X.; Li, Y.; Li, W.; Zhang, B.; Wang, A. J.; Sun, J.; Mikule, K.; Jiang, Z.; Li, C. J.
Selective induction of necrotic cell death in cancer cells by beta-lapachone through activation of DNA damage response pathway
Cell Cycle Vol. 5 (17) 2029-35. Sep. 2006
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Xiang, S.; Fruehauf, J.; Li, C. J.
Short hairpin RNA-expressing bacteria elicit RNA interference in mammals
Nat Biotechnol Vol. 24 (6) 697-702. Jun. 2006
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Frame, F. M.; Rogoff, H. A.; Pickering, M. T.; Cress, W. D.; Kowalik, T. F.
E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts
Oncogene Vol. 25 (23) 3258-66 Jun 1, 2006
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Wang, A.; Li, C. J.; Reddy, P. V.; Pardee, A. B.
Cancer chemotherapy by deoxynucleotide depletion and E2F-1 elevation
Cancer Res Vol. 65 (17) 7809-14. Sep 1, 2005
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Chen, C. R.; Wang, W.; Rogoff, H. A.; Li, X.; Mang, W.; Li, C. J.
Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: checkpoint activation as a strategy against cancer
Cancer Res Vol. 65 (14) 6017-21. Jul 15, 2005
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Doxsey, S.; Zimmerman, W.; Mikule, K.
Centrosome control of the cell cycle
Trends Cell Biol Vol. 15 (6) 303-11. Jun 2005
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Pardee, A. B.; Li, C. J.; Reddy, G. P.
Regulation in S phase by E2F
Cell Cycle Vol. 3 (9) 1091-4. Sep. 2004
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Rogoff, H. A.; Kowalik, T. F.
Life, death and E2F: linking proliferation control and DNA damage signaling via E2F1 Cell Cycle Vol. 3 (7) 845-6. Jul. 2004
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Rogoff, H. A.; Pickering, M. T.; Frame, F. M.; Debatis, M. E.; Sanchez, Y.; Jones, S.; Kowalik, T. F.
Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2
Mol Cell Biol Vol. 24 (7) 2968-77. Apr. 2004
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Li, Y.; Sun, X.; LaMont, J. T.; Pardee, A. B.; Li, C. J.
Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer
Proc Natl Acad Sci U S A Vol. 100 (5) 2674-8. Mar 4, 2003
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Pardee, A. B.; Li, Y. Z.; Li, C. J.
Cancer therapy with beta-lapachone
Curr Cancer Drug Targets Vol. 2 (3) 227-42. Sep. 2002
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Li, Y.; Li, C. J.; Yu, D.; Pardee, A. B.
Potent induction of apoptosis by beta-lapachone in human multiple myeloma cell lines and patient cells
Mol Med Vol. 6 (12) 1008-15. Dec. 2000
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Li, C. J.; Li, Y. Z.; Pinto, A. V.; Pardee, A. B.
Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: combining drugs imposes different artificial checkpoints
Proc Natl Acad Sci U S A Vol. 96 (23) 13369-74. Nov 9, 1999
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Li, Y. Z.; Li, C. J.; Pinto, A. V.; Pardee, A. B.
Release of mitochondrial cytochrome C in both apoptosis and necrosis induced by beta-lapachone in human carcinoma cells
Mol Med Vol. 5 (4) 232-9 Apr. 1999
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Li, C. J.; Wang, C.; Pardee, A. B.
Induction of apoptosis by beta-lapachone in human prostate cancer cells
Cancer Res Vol. 55 (17) 3712-5. Sep 1,1995
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