Cancer Stem Cells

A Role in Cancer Recurrence and Metastasis1

Despite current advances in cancer therapy, tumor recurrence and metastasis remain clinically challenging.2 Cancer stem cells (CSCs) are a highly tumorigenic subset of the total cancer cell population.3,4 While chemotherapy and radiation have been shown to affect the majority of tumor cells, CSCs may be highly resistant to these therapies, resulting in tumor recurrence and metastasis.1,5 Moreover, conventional chemotherapy and radiation therapy may induce stemness in non-stem cancer cells.3,6

Boston Biomedical is committed to developing cancer therapeutics designed to inhibit cancer stem cell pathways.

Characteristics of Cancer Stem Cells

CSCs are thought to possess 4 key characteristics:

Cancer Stemness: A Puzzle Piece of Cancer
Understand how cancer stemness impacts growth of malignant tumors and may explain tumorigenicity and tumor recurrence. Download this slide deck resource.

References

  1. Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med. 2006;355(12):1253-1261.
  2. Li Y, Rogoff HA, Keates S, et al. Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc Nat Acad Sci USA. 2015;112(6):1839-1844.
  3. Hu X, Ghisolfi L, Keates AC, et al. Induction of cancer stemness by chemotherapy. Cell Cycle. 2012;11(14):2691-2698.
  4. Clarke MF. Self-renewal and solid-tumor stem cells. Biol Blood Marrow Transplant. 2005:11(2 suppl 2):14-16.
  5. Boman BM, Huang E. Human colon cancer stem cells: a new paradigm in gastrointestinal oncology. J Clin Oncol. 2008;26(17):2828-2838.
  6. Ghisolfi L, Keates AC, Hu X, Lee DK, Li CJ. Ionizing radiation induces stemness in cancer cells. PLoS ONE. 2012;7(8):ea43628.

Cancer Stem Cells and Stemness in the Biology of Cancer: An Expert Analysis

Cancer Stemness: A Puzzle Piece of Cancer

Understand how cancer stemness impacts growth of malignant tumors and may explain tumorigenicity and tumor recurrence. Download this slide deck resource.Download Now

Current Clinical Trials

Our ongoing studies in advanced cancers emphasize inhibition of cancer stem cell pathways.Learn More