Cancer Stem Cells
A Role in Cancer Recurrence and Metastasis1
Despite current advances in cancer therapy, tumor recurrence and metastasis remain clinically challenging.2 Cancer stem cells (CSCs) are a highly tumorigenic subset of the total cancer cell population.3,4 While chemotherapy and radiation have been shown to affect the majority of tumor cells, CSCs may be highly resistant to these therapies, resulting in tumor recurrence and metastasis.1,5 Moreover, conventional chemotherapy and radiation therapy may induce stemness in non-stem cancer cells.3,6
Boston Biomedical is committed to developing cancer therapeutics designed to inhibit cancer stem cell pathways.
Characteristics of Cancer Stem Cells
CSCs are thought to possess 4 key characteristics:
- Stemness—the capacity to self-renew and differentiate into cancer cells
- Aberrant signaling pathways
- Resistance to traditional therapies
- The ability to contribute to tumor recurrence and metastasis
- Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med. 2006;355(12):1253-1261.
- Li Y, Rogoff HA, Keates S, et al. Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc Nat Acad Sci USA. 2015;112(6):1839-1844.
- Hu X, Ghisolfi L, Keates AC, et al. Induction of cancer stemness by chemotherapy. Cell Cycle. 2012;11(14):2691-2698.
- Clarke MF. Self-renewal and solid-tumor stem cells. Biol Blood Marrow Transplant. 2005:11(2 suppl 2):14-16.
- Boman BM, Huang E. Human colon cancer stem cells: a new paradigm in gastrointestinal oncology. J Clin Oncol. 2008;26(17):2828-2838.
- Ghisolfi L, Keates AC, Hu X, Lee DK, Li CJ. Ionizing radiation induces stemness in cancer cells. PLoS ONE. 2012;7(8):ea43628.