Stemness Signaling Pathways Are Dysregulated in Cancer Stem Cells
In normal stem cells, stemness signaling pathways are tightly controlled and genetically intact. In contrast, stemness signaling pathways in cancer stem cells (CSCs) are dysregulated, allowing these cells to self-renew and differentiate into cancers cells.1
Cancer Stemness Signaling Pathways
Key stemness signaling pathways involved in the induction and maintenance of stemness in CSCs include2-4:
Targeting these signaling pathways may disrupt aberrant signaling in CSCs, potentially reducing cancer recurrence and metastasis.5
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