Cancer Stem Cells and Resistance to Traditional Therapies
Cancer stem cells (CSCs) have been identified in a variety of tumor types. Evidence suggests that these cells possess considerable resistance to conventional chemotherapy and radiation.1 Thus, typical therapeutic strategies that target actively proliferating cancer cells may yield bulk tumor shrinkage while allowing a population of CSCs to survive.2
Stemness Signaling Pathways and Resistance to Therapy
The relatively slow rate of proliferation of CSCs may confer protection against traditional therapies.3 The tumor microenvironment and aberrant regulation of signaling pathways also contribute to CSCs’ resistance to radiation and chemotherapy.4
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oncology. J Clin Oncol. 2008;26(17):2828-2838.
- Borovski T, De Sousa E, Melo F, Vermeulen L, Medema JP. Cancer stem cell niche: the place to be. Cancer Res. 2011;71(3):634-639.