Targeting Cancer Cell Subsets

Understanding the Heterogeneity of Cancer Cell Populations

Despite current advances in cancer therapy, tumor recurrance and metastases remain clinical challenges.1 A potentional new approach to address these is the simultaneous targeting of mature, differentiated tumor cells and an undifferentiated subset of the tumor cell population known as cancer stem cells (CSCs).2,3 The heterogeneity of the tumor due to this spectrum of cell subsets points to the need for multitargeted approaches.1

A Closer Look at Two Cancer Cell Subsets That May Drive Tumor Progression

At a high level, cancer cells can be categorized into two subsets: differentiated cancer cells and undifferentiated CSCs. Differentiated cancer cells sustain and increase the volume of local tumors but lack the ability to self-renew. CSCs, however, possess the ability to self-renew and differentiate, which enables them to originate tumors and metastasize.3,5

Notably, cancer cells can also dedifferentiate in response to multiple stimuli, possibly including conventional cancer therapies.3,6

The Persistance of CSCs May Help Explain Tumor Recurrence

While conventional therapies kill the bulk of differentiated cancer cells, resulting in tumor shrinkage, CSCs may remain viable and later reestablish the tumor, leading to relapse.7 The persistence of CSCs despite therapy could help explain why some tumors recur even after an initial reduction in size.8

Therefore, targeting both CSCs and differentiated cancer cells may be a rational therapeutic strategy.2

Boston Biomedical is a leading developer of the next-generation of cancer therapeutics designed to inhibit multiple oncogenic pathways.


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